Publications

Prevalence, Risk Factors, and Intervention Development.

(18) Hanley AJ, McKeown-Eyssen G, Harris SB, Hegele RA, Wolever TM, Kwan J, Zinman B. Association of Parity with Risk of Type 2 Diabetes and Related Metabolic Disorders. Diabetes Care. 2002 Apr;25(4):690-695.

(17) Harris SB, Zinman B, Hanley A, Gittelson J, Hegele R, Connelly PW, Shah B, Hux JE. The Impact of Diabetes on Cardiovascular Risk Factors and Outcomes in a Native Canadian Population. Diabetes Res Clin Pract. 2002 Feb;55(2):165-173.

(16) Hanley AJ, McKeown-Eyssen G, Harris SB, Hegele RA, Wolever TM, Kwan J, Zinman B. Cross-sectional and Prospective Associations between Abdominal Adiposity and Proinsulin Concentration. J Clin Endrocrinol Metab. 2002 Jan;87(1):77-83.

(15) Kriska AM, Hanley AJ, Harris SB, Zinman B. Physical Activity, Physical Fitness, and Insulin and Glucose Concentrations in an Isolated Native Canadian Population Experiencing Rapid Lifestyle Change. Diabetes Care. 2001 Oct;24(10):1787-92.

(14) Hanely AJ, McKeown-Eyssen G, Harris SB, Hegele RA, Wolever TM, Kwan J, Connelly PW, Zinman B. Cross-sectional and Prospective Associations between Proinsulin and Cardiovascular Disease Risk Factors in a Population Experiencing Rapid Cultural Transition. Diabetes Care. 2001 Jul;24(7):1240-7.

(13) Harris SB, Zinma, B. Primary Prevention of Type 2 Diabetes in High-Risk Populations. Diabetes Care. 2000 Jul;23(7):879-81.

(12) Hanley AJG, Harris SB, Gittelsohn J, Wolever TMS, Saksvig B, Zinman B. Overweight among children and adolescents in a Native Canadian community: prevalence and associated factors. Am J Clin Nutr 2000;71:693-700.

(11) Zinman B, Hanley AJG, Harris SB, Kwan J, Fantus IG. Circulating tumor necrosis factor alpha (TNF-a ) concentrations in a Native Canadian community with high rates of type 2 diabetes mellitus. J Clin Endocrinol Metab 1999;84:272-8.

(10) Gittelsohn J, Wolever TMS, Harris SB, Harris-Giraldo R, Hanley AJG, Zinman B. Specific patterns of food consumption and preparation are associated with diabetes and obesity in a Native Canadian Community. Journal of Nutrition 1998;128:541-547

(9) Hanley AJG, Harris SB, Zinman B. Application of revised American Diabetes Association criteria for the diagnosis of diabetes in a Canadian Native population. Diabetes Care 1998;21:870-871.

(8) Wolever TMS, Hamad S, Gittelsohn J, Gao XJ, Hanley ALG, Harris SB, Zinman B. Low dietary fibre and high protein intakes associated with newly diagnosed diabetes in a remote aboriginal community. Am J Clin Nutr 1997;66:1470-4.

(7) Hanley AJG, Harris SB, Gao XJ, Kwan J, Zinman B. Serum immunoreactive-leptin concentrations in a Canadian aboriginal population with high rates of non-insulin-dependant diabetes mellitus Diabetes Care 1997;20:1408-15.

(6) Wolever TMS, Hamad S, Gittelsohn J, Hanley AJG, Logan A, Harris SB, Zinman B. Nutrient intake and food use in an Ojibwa-Cree community in northern Ontario assessed by 24h dietary recall. Nutrition Research 1997;17:603-18.

(5) Harris SB, Gittelsohn J, Hanley AJG, Barnie A, Wolever TMS, Gao XJ, Logan A, Zinman B. The prevalence of NIDDM and associated risk factors in Native Canadians. Diabetes Care 1997;20:185-187.

(4) Gittelsohn J, Harris SB, Thorne-Lyman A, Hanley AJG, Barnie A, Zinman B. Body image in an isolated Ojibway-Cree community in Canada. Journal of Nutrition 1996;126:2990-3000.

(3) Gittelsohn J, Harris SB, Burris K, Kakegamic L, Landman L, Sharma A, Wolever TMS, Barnie A, Zinman B. Use of ethnographic methods for applied research on diabetes among Ojibway-Cree Indians in Northern Ontario. Health Educ Q 23:365-382, 1996.

(2) Hanley AJG, Harris SB, Barnie A, Gittelsohn J, Wolever TMS, Logan A, Zinman B. The Sandy Lake Health and Diabetes Project: Design, methods, and lessons learned. Chronic Dis Can 1995;16:149-156.

(1) Gittelsohn J, Harris SB, Whitehehad S, Wolever TMS, Hanley AJG, Barnie A, Kakegamic L, Logan A, Zinman B. Developing diabetes interventions in an Ojibwa-Cree community in northern Ontario: Linking qualitative and quantitative data. Chronic Dis Can 1995;16:157-164.

Additions to Genetic Publications Section

(37) Triggs-Raine BL, Kirkpatrick RD, Kelly SL, Norquay LD, Cattini PA, Yamagata K, Hanley AJ, Zinman B, Harris SB, Barrett PH, Hegele RA.
HNF-1 alphaG319S, a Transactivation-deficient mutant, is assoicated with altered dynamics of diabetes onset in an Oji-Cree community. Proc Natl Acad Sci USA. 2002 Apr2;99(7):4614-4619.

(36) Mok A, Cao H, Zinman B, Hanley AJ, Harris SB, Kennedy BP, Hegele RA.A Single Nucleotide polymorphism in Protein Tyrosine Phosphatase PTP-1B is associated with protection from diabetes or Impaired Glucose Tolerance in Oji-Cree. J Clin Endocrinol Metab. 2002 Feb;87(2):724-7.

(35) Hegele RA, Harris SB, Zinman B, Hanley AJ, Cao H. Absence of association of type 2 diabetes with CAPN10 and PC-1 polymorphism in Oji-Cree. Diabetes Care 2001. Aug;24(8):1498-9.

(34) Hegele RA, Wang J, Harris SB, Brunt JH, Young TK, Hanley Aj, Zinman B, Connelly PW, Anderson CM. Variable association between genetic variation in the CYP7 gene promoter and plasma lipoproteins in three Canadian populations. Atherosclerosis. 2001 Feb 15;154(3):579-87.

(33) Hegele RA, Cao H, Harris SB, Zinman B, Hanley AJ, Anderson CM.
Genetic variation in LMNA modulates plasma leptin and indices of obesity in aboriginal Canadians. Physiol Genomics. 2000 Jun 29;3(1):39-44.

(32) Fanela S, Harris SB, Young TK, Hanley AJ, Zinman B, Connelly PW, Hegele RA. Association between P0N1 L/M55 polymorphism and plasma lipoprotiens in two Canadian Aboriginal Populations. Clin Chem Lab Med. 2000 May;38(5):413-20.

(31) Hegele RA, Cao H, Harris SB, Zinman B, Hanley AJ, Anderson CM. Gender, Obesity hepatic nuclear factor-1 alpha G319S and the age-of-onset of type 2 diabetes in Canadian Oji-Cree. Int J Obes Relat Metab Disord. 2000 Aug;24(8):1062-4.

(30) Wang J, Burnett JR, Near S, Young TK, Zinman B, Hanley AJ, Connelly PW, Harris SB, Hegele RA. Common and Rare ABCA1 variants affecting plasma HDL cholesterol. Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):1983-9.

(29) Hegele RA, Cao H, Harris SB, Zinman B, Hanley AJ, Anderson CM.
Peroxisome Proliferator-activated recptor-gamma2P12A and type 2 diabetes in Canadian Oji-Cree. J Clin Endocrinol Metab. 2000. May;85(5):2014-9.

(28) Hegele RA, Cao H, Hanley AJ, Zinman B, Harris SB, Anderson CM.
Clinical Utility of HNF1A Genotyping for Diabetes in Aboriginal Canadians. Diabetes Care. 2000. Jun;23(6):775-8.

(27) Hegele RA, Hanley AJ, Zinman B, Harris SB, Anderson CM.
Disparity between association and likage analysis for HNF1A G319S in Type 2 Diabetes in Canadian Oji-Cree. J Hum Genet. 2000;45(3):184-7.

(26) Hegele RA, Kwan K, Harris SB, Hanley AJ, Zinman B, Cao H.
NAT2 polymorphism associated with plasma glucose concentration in Canadian Oji-Cree. Pharmacogenetics. 2000 Apr;10(3):233-8.

(25) Hegele RA, Cao H, Harris SB, Hanley AJ, Zinman B, Connelly PW.
The Private hepayocyte nuclear factor-1alpha G319S variant is associated with plasma lipoprotein variation in Canadian Oji-Cree. Arterioscler Throm Vasc Biol. 2000 Jan;20(1):217-22.

(23) Hegele RA, Hanley AJG, Zinman B, Harris SB, Anderson CM. Youth-onset type 2 diabetes (Y2DM) associated with HNF1A S319 in aboriginal Canadians. Diabetes Care 1999;22:2095-6.

(22) Hegele RA, Harris SB, Hanley AJG, Cao H, Zinman B. G-protein b3 subunit gene variant and blood pressure variation in Canadian Oji-cree. Hypertension 1998;32:688-92.

(21) Hegele RA, Cao H, Harris SB, Hanley AJG, Zinman B. The hepatic nuclear factor-1a G319S variant is associated with early onset type 2 diabetes in Canadian Oji-Cree. J Clin Endocrinol Metab 1999;84:1077-82.

(20) Hegele RA, Cao H, Harris SB, Hanley AJG, Zinman B. HNF-1a G319S: a private mutation in Oji-Cree associated with type 2 diabetes. Diabetes Care 1999:22:524.

(19) Hegele RA, Harris SB, Brunt JH, Young TK, Hanley AJG, Zinman B, Connelly PW. Absence of association between genetic variation in the LIPC gene promoter and plasma lipoproteins in three Canadian populations. Atherosclerosis 1999;146:153-60.

(18) Hegele RA, Harris SB, Hanley AJG, Zinman B. Association between AGT codon 235 polymorphism and variation in serum concentrations of creatinine and urea in Canadian Oji-Cree. Clin Genet 1999;55:438-43.

(17) Busch CP, Harris SB, Hanley AJG, Zinman B, Hegele RA. The ADD1 G460W polymorphism is not associated with variation in blood pressure in Canadian Oji-Cree. J Hum Genet 1999;44:225-9.

(16) Hegele RA, Harris SB, Hanley AJG, Zinman B. Association between AGT T235 variant and microalbuminuria in Canadian Oji-Cree with type 2 diabetes mellitus. Clin Biochem 1999;32:201-5.

(15) Hegele RA, Harris SB, Zinman B, Hanley AJG, Connelly PW. Increased plasma apolipoprotein B-containing lipoproteins associated with increased urinary albumin within the microalbuminuria range in type 2 diabetes. Clin Biochem 1999 32:143-8.

(14) Hegele RA, Sun F, Harris SB, Anderson C, Hanley AJG, Zinman B. Genome-wide scanning for type 2 diabetes susceptibility in Canadian Oji-Cree, using 190 microsatellite markers. J Hum Genet 1999;44(1):10-4.

(13) Hegele RA, Harris SB, Connelly PW, Hanley AJG, Tsui LC, Zinman B, Scherer SW. Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree. Clin Genet 1998 54(5):394-9.

(12) Hegele RA, Harris SB, Zinman B, Wang J, Cao H, Hanley AJG, Tsui, L-C, Scherer SW. Variation in the Au(AT)-rich element within the 3’untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians. J Clin Endocrinol Metab 1998;83:3980-3983.

(11) Hegele RA, Harris SB, Hanley AJG, Azouz H, Connelly PW, Zinman B. Absence of association between genetic variation of the b 3-adrenergic receptor and metabolic phenotypes in Oji Cree. Diabetes Care 1998;21:851-4.

(10) Hegele RA, Harris SB, Cao H, Hanley AJG, Zinman B. Factor V Leiden (F5Q506) and vascular disease in Canadian Oji-Cree (letter). Diabetes Care 1998;21:1203.

(9) Hegele RA, Harris SB, Hanley AJG, Sun F, Connelly PW, Zinman B. -6A promoter variant of angiotensinogen and blood pressure variation in Canadian Oji-Cree. J Hum Genet 1998;43:37-41.

(8) Hegele RA, Wolever TMS, Hanley AJG, Harris SB, Zinman BZ. Methylenetetrahydrofolate reductase gene, dietary folate, NIDDM, and atherosclerosis in Canadian Oji-Cree. Diabetes Care 1998;21:322-323.

(7) Hegele RA, Connelly PW, Hanley AJG, Sun F, Harris SB, Zinman B. Common genomic variation in the APOC3 promoter associated with variation in plasma lipoproteins. Arterioscler Thromb Vasc Biol 1997;17:2753-2758.

(6) Hegele RA, Connelly PW, Scherer SW, Hanley AJG, Harris SB, Tsui L-C, Zinman B. Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1997;82:3373-7.

(5) Hegele RA, Connelly PW, Scherer SW, Hanley AJG, Harris SB, Tsui L-C, Zinman B. Paraoxonase-2 G148 variant in an aboriginal Canadian girl with non-insulin-dependent diabetes. Lancet 1997;350:785.

(4) Hegele RA, Zinman B, Hanley AJG, Harris SB, Connelly PW. A common mtDNA polymorphism associated with variation in plasma triglyceride concentration. Am J Hum Genet 1997;60:1552-55.

(3) Hegele RA, Harris SB, Hanley AJG, Sun F, Connelly PW, Zinman B. Angiotensinogen gene variation associated with variation in blood pressure in Aboriginal Canadians. Hypertension 1997;29:1073-77.

(2) Hegele RA, Connelly PW, Hanley AJG, Sun F, Harris SB, Zinman B. Common genomic variants associated with variation in plasma lipoproteins in young aboriginal Canadians. Arterioscler Thromb Vasc Biol 1997;17:1060-1066.

(1) Hegele RA, Harris SB, Hanley AJG, Sadikian S, Connelly, PW, Zinman B. Genetic variation of intestinal fatty acid-binding protein associated with variation in body mass in aboriginal Canadians. J Clin Endocrinol Metab 1996;81:4334-4337.